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Knopf Doubleday Publishing Group

The Ego Trip

The Ego Trip

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ISBN:
9780385550246
Pages:
336
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Release Date:
Aug 4, 2026

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A lost tradition of "toad medicine," a global psychedelic movement, and the charismatic doctor who left a trail of destruction in his wake

“Entirely mesmerizing. . . . Richly reported and written with humor and flair, The Ego Trip is itself a trip—and Kimon de Greef is a major talent.” —Patrick Radden Keefe, #1 New York Times bestselling author of London Falling

“Toad-laced psychopathy is one hell of a drug. . . . An enthralling, galling journey into the deeply weird underbelly of the psychedelic renaissance.” —The New York Times


In 2012, a Mexican doctor named Octavio Rettig declared that he had revived a forgotten indigenous ritual: smoking the secretions of the Sonoran Desert toad, which releases a potent psychedelic substance known as “the God molecule.” This enormously powerful drug can induce states of ego death and the sensation of being directly connected with the divine. In some cases, it offers profound relief for numerous conditions and illnesses. Drawn in by Octavio's visionary message of healing, many psychonauts, spiritual seekers, and patients without other options flocked to Sonora and sparked a psychedelic movement that would eventually circle the globe. But as Octavio's fame grew, stories emerged of extreme dosing, abusive behavior, and even dramatic deaths.

In this gripping and deeply reported book, Kimon de Greef uncovers the truth behind this cultish figure and the wider world of toad medicine. While Octavio touted the cultural authenticity of his toad ceremonies, verifiable evidence of ancestral practice appeared questionable. Fractious turf wars broke out among toad collectors, who sent impoverished locals into drug cartel territory to chase after the animals and risk their lives in the process. And pharmaceutical companies raced against one another to profit from the commercial potential of the God molecule and develop a transformative mental health treatment that could rival Prozac in its impact on psychopharmacology.

Part true crime, part cult story, part cultural history, The Ego Trip is a chronicle of the rise and fall of a messianic figure and an investigation into larger truths about our age of spiritual desolation. As de Greef makes clear in this hypnotic story, no matter the lengths we go to in attaining a more cosmic understanding, we will always remain firmly in the real world, bound by our limitations and inescapably human.

STANDARD, PRIMARY, DM AND VARIANT COVERS

Standard and Primary covers are widely available through general retailers. They often have higher print runs and can be cheaper, especially during sales.

In contrast, Direct Market (DM) and variant covers are primarily sold in comic shops. DM editions tend to have more limited availability and may be more valuable to collectors.

The main differences lie in artwork style, availability, price, and collector appeal. Ultimately, the choice between standard and variant covers depends on personal preference, budget, and individual collecting goals.

PRODUCT TYPES

Comic book enthusiasts have various formats to choose from when collecting their favorite stories.
Here's a brief overview of the main types:

Omnibus

  • Large, hardcover collections
  • Usually contain complete runs or extensive story arcs
  • Typically 800-1000+ pages
  • Higher price point, often €100-€150

Oversized Hardcover (OHC)

  • Similar dimensions to omnibus, but thinner
  • Collect shorter runs or story arcs
  • Usually 300-600 pages
  • Priced between €30-€50

Hardcover (HC)

  • Standard-sized hardcover books
  • Collect 6-12 issues typically
  • Similar dimensions to single issues, but with a hard cover
  • Priced around €25-€35

Trade Paperback (TP)

  • Softcover collections
  • Standard comic book size
  • Usually collect 4-6 issues
  • Most affordable option, typically €15-€25

Other Formats

  • Absolute Editions: Oversized, deluxe hardcovers (mainly DC Comics)
  • Compendiums: Massive paperback collections
  • Graphic Novels (OGN/GN): Original stories not previously released as single issues

The choice between these formats often depends on personal preference, budget, and collecting goals. Omnibus and OHC editions offer larger artwork and more content but at a higher price, while TPs provide a more affordable way to collect complete story arcs