Knopf Doubleday Publishing Group
Tyranny of the Gene
Tyranny of the Gene
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ABOUT
The United States is embarking on a medical revolution. Supporters of personalized, or precision, medicine—the tailoring of health care to our genomes—have promised to usher in a new era of miracle cures. Advocates of this gene-guided health-care practice foresee a future where skyrocketing costs can be curbed by customization and unjust disparities are vanquished by biomedical breakthroughs. Progress, however, has come slowly, and with a price too high for the average citizen.
In Tyranny of the Gene, James Tabery exposes the origin story of personalized medicine—essentially a marketing idea dreamed up by pharmaceutical executives—and traces its path from the Human Genome Project to the present, revealing how politicians, influential federal scientists, biotech companies, and drug giants all rallied behind the genetic hype. The result is a medical revolution that privileges the few at the expense of health care that benefits us all.
Now American health care, driven by the commercialization of biomedical research, is shifting focus away from the study of the social and environmental determinants of health, such as access to fresh and nutritious food, exposure to toxic chemicals, and stress caused by financial insecurity. Instead, it is increasingly investing in “miracle pills” for leukemia that would bankrupt most users, genetic studies of minoritized populations that ignore structural racism and walk dangerously close to eugenic conclusions, and oncology centers that advertise the perfect gene-drug match, igniting a patient’s hope, and often dashing it later.Tyranny of the Gene sounds a warning cry about the current trajectory of health care and charts a path to a more equitable alternative.
STANDARD, PRIMARY, DM AND VARIANT COVERS
Standard and Primary covers are widely available through general retailers. They often have higher print runs and can be cheaper, especially during sales.
In contrast, Direct Market (DM) and variant covers are primarily sold in comic shops. DM editions tend to have more limited availability and may be more valuable to collectors.
The main differences lie in artwork style, availability, price, and collector appeal. Ultimately, the choice between standard and variant covers depends on personal preference, budget, and individual collecting goals.
PRODUCT TYPES
Comic book enthusiasts have various formats to choose from when collecting their favorite stories.
Here's a brief overview of the main types:
Omnibus
- Large, hardcover collections
- Usually contain complete runs or extensive story arcs
- Typically 800-1000+ pages
- Higher price point, often €100-€150
Oversized Hardcover (OHC)
- Similar dimensions to omnibus, but thinner
- Collect shorter runs or story arcs
- Usually 300-600 pages
- Priced between €30-€50
Hardcover (HC)
- Standard-sized hardcover books
- Collect 6-12 issues typically
- Similar dimensions to single issues, but with a hard cover
- Priced around €25-€35
Trade Paperback (TP)
- Softcover collections
- Standard comic book size
- Usually collect 4-6 issues
- Most affordable option, typically €15-€25
Other Formats
- Absolute Editions: Oversized, deluxe hardcovers (mainly DC Comics)
- Compendiums: Massive paperback collections
- Graphic Novels (OGN/GN): Original stories not previously released as single issues
The choice between these formats often depends on personal preference, budget, and collecting goals. Omnibus and OHC editions offer larger artwork and more content but at a higher price, while TPs provide a more affordable way to collect complete story arcs